American Physiology Professor Horatio Burt Williams (1877-1955) designed a respiration calorimeter for the Physiology Laboratory at New York Cornel Medical College.
A dog with a rectal thermometer mounted on a tape lay in a cage that could be placed into the calorimetry chamber. The animal breathed into the calorimeter's chamber, the water and the carbonic acid that it separated were removed by passing the air through absorbent chemicals and oxygen was supplied simultaneously to replace the spent oxygen. The heat produced by the dog was discharged via a water flow through pipes.